The following criteria is provided for health care professionals.

Inclusion Criteria:

• Participants must be greater than or equal to 18 years of age.
• Participants must have been diagnosed with multiple myeloma in a first or subsequent remission and have undergone a successful pre-transplant work up and are otherwise eligible for an autotransplant with a busulfan/melphalan preparative regimen at Loyola University Medical Center.
• Participants may receive this preparative regimen if in first or subsequent remission. Participants may enter if they have received a prior autologous stem cell transplant and this therapy produced a remission that lasted greater than 18 months before progression of disease. Participants who have undergone prior allogeneic transplantation are excluded.
• All participants must have responsive disease as defined by a Partial Response or greater to most recent conventional regimen.
• Participants receiving prior carfilzomib will be eligible for inclusion provided they demonstrated responsive disease to this agent and either had a remission that lasted greater than 6 months after its discontinuance, or if in remission after a carfilzomib containing regimen administered to qualify for transplant.
• Participants must have an Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) less than or equal to 2.
• Acceptable heart function test.

Exclusion Criteria:

• Participants must not have below normal kidney function.
• Participants must not have below normal liver function.
• Participants must not have active bacterial, fungal, or viral infection.
• Participants must not have severe lung function.
• Participants must not have Grade 2 or greater peripheral neuropathy.
• Participants must not have uncontrolled hypertension.