This trial is testing the safety of Anti-SLAMF7 CAR-T cells in myeloma. The Anti-SLAMF7 CAR-T cells in this trial are altered to include a ‘stop switch’, to help limit toxicity of this therapy.
This trial is open but patient recruitment is temporarily on hold.
This Phase 1 trial is being run in two different arms, dose escalation and dose expansion. It is non-randomized, with sequential assignment, which means that the dose you receive, or the trial arm you enroll in, depend on when you join the trial. It is also open label, which means that both the researchers and you will know which dose you are receiving, or arm you are participating in.
If patients develop bad side effects from the Anti-SLAMF7, researchers can decide to give them Rimiducid by intravenous infusion to cause cell death of the Anti-SLAMF7 CAR-T cells.
Enrollment: 42 patients (estimated)View More
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