Melflufen is a peptide-conjugated alkylator (a new type of cancer therapy) that rapidly delivers a toxic drug payload into myeloma cells, resulting in myeloma cell death.
View all active clinical trials around the US.
The following is a listing of clinical trials for patients with multiple myeloma who have received one to two prior lines of therapy.
The following is a listing of clinical trials for patients with multiple myeloma who have received three or more prior lines of therapy.
June 11, 2019
According to an abstract of data from ANCHOR, of the 10 patients in the arm receiving melflufen with Darzalex there was a 100 percent overall response rate (ORR) at the 30mg dose cohort and a 50 percent response rate at the 40mg cohort. For the five receiving melflufen and bortezomib, the response rate was 100 percent in the 30mg cohort and zero percent at the 40mg dose.
Meanwhile, the company is planning to pursue accelerated FDA approval based on the HORIZON study, with a regulatory filing anticipated in early 2020. According to the EHA abstract for that study, the median PFS for the 95 patients treated as of the Feb. 6 cutoff was four months, with a 10 month median overall survival (OS) and an ORR of 30 percent. Data presented at ASH from a previous cutoff date showed a 33 percent ORR.