Myeloma Clinical Trials

There are hundreds of clinical trials for patients with Multiple Myeloma, Smoldering Myeloma and Monoclonal Gammopathy of Undetermined Significance (MGUS) around the US. Below is a featured listing of clinical trials to help you get started. Please use the options on the side bar to find trials based on your diagnosis.


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Recently Updated

Open-label, randomized study of two doses of GSK2857916 in participants with relapsed / refractory multiple myeloma who have failed prior treatment of an anti-CD38 antibody and are refractory to an immunomodulatory agent and a proteasome inhibitor

This research study is being done to learn more about multiple myeloma and if the study drug, GSK2857916, can improve multiple myeloma in patients who have already failed other treatments.

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Study of bb2121 in Multiple Myeloma

Study CRB-401 is a 2-part, non-randomized, open label, multi-site Phase 1 study of bb2121 in adults with relapsed/refractory multiple myeloma (MM).

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A Phase 1 Study of the Safety and Efficacy of CAR2 Anti-CD38 A2 CAR-T Cells in Patients with Relapsed or Refractory Multiple Myeloma

This is an investigational study of CAR2 Anti-CD38 A2 CAR-T Cells in patients with Relapsed or Refractory Multiple Myeloma. The treatment uses your own T cells to try to kill your cancerous multiple myeloma cells.

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Immunotherapy With BCMA CAR-T Cells in Treating Patients With BCMA Positive Relapsed or Refractory Multiple Myeloma

This phase I trial studies the side effects and best dose of BCMA CAR-T cells in treating patients with BCMA positive multiple myeloma that has come back or does not respond to treatment.

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Recently Updated

Study of CD8+ anti-BCMA CAR T-cells in Patients with Multiple Myeloma

This Phase 1 study will evaluate the safety and feasibility of an investigational CAR-T cell therapy called Descartes-08 in eligible patients with active multiple myeloma.

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The INSIGHT MM Study: A global, prospective, non-interventional, observational study of presentation, treatment patterns, and outcomes in multiple myeloma

The INSIGHT MM study is an observational study that may provide a better understanding of current multiple myeloma patients globally, and ways in which they are cared for after they are diagnosed. By participating, you are helping researchers evaluate the effectiveness of interventions for treating diseases in a real-world setting, which can give doctors a better understanding of the health outcomes of complex medical conditions.

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A Phase 1/2a Study Investigating TAK-079 Administered Subcutaneously in Patients With Relapsed/Refractory Multiple Myeloma

This is a phase 1/2a study evaluating the safety, tolerability and the most appropriate dose, of TAK-079 monotherapy as treatment for patients with Relapsed/Refractory Multiple Myeloma.

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A Safety Study of SGN-CD48A in Patients With Multiple Myeloma

This study will test the safety and activity of SGN-CD48A given every 3 weeks to patients with multiple myeloma.

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Recently Updated

An Investigational Immuno-Therapy Study to Determine the Safety and Effectiveness of Nivolumab and Daratumumab in Patients With Multiple Myeloma

The purpose of this study is to determine the side effects of treatment of the combination of nivolumab and daratumumab in participants with relapsed/refractory multiple myeloma.

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A phase 1 study of SEA-BCMA in patients with relapsed or refractory multiple myeloma

This is a phase 1 study of SEA-BCMA, a type of treatment called a monoclonal antibody. Antibodies are part of your immune system. Usually, they help protect you from getting sick. With SEA-BCMA, we are using an antibody designed to stick to the multiple myeloma cells in your body. The antibody sends a signal to other cells in your immune system that kill the cancer cells.

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Bortezomib, Selinexor, and Dexamethasone in Patients With Multiple Myeloma

This study will compare the efficacy and health-related quality of life (HR-QoL) and assess the safety of selinexor plus bortezomib (Velcade or generic equivalent) plus low-dose dexamethasone (SVd) versus bortezomib plus low-dose dexamethasone (Vd) in adult patients with relapsed or refractory multiple myeloma.

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Study of Precursor Hematological Malignancies to Assess the Relationship between Molecular Events of Progression and Clinical Outcome (PCROWD)

The PCROWD is part of the Center for Prevention of Progression of Blood Cancers (CPOP), a research initiative at Dana-Farber Cancer Institute focused on understanding the progression and clonal evolution of blood cancers, with an ultimate aim to develop targeted therapeutic agents that can eliminate the early clones of disease.

No travel is required to participate in this observational trial.

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Study of Bromodomain and Extra-Terminal Protein (BET) Inhibitor RO6870810 as Mono- and Combination Therapy in Advanced Multiple Myeloma

The purpose of this study is to test whether RO6870810 is safe at different dose levels, to find out what effects, good or bad, RO6870810 has on you and your disease as monotherapy or in combination with daratumumab in participants with relapsed/refractory multiple myeloma.

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Ohio State University Multiple Myeloma and Amyloidosis Data Registry and Sample Resource

The investigators are researching patients with diseases of their plasma cells in order to improve their quality and length of life.

No travel is required to participate in this observational trial.

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PRospective Multiple Myeloma Impact Study (PROMMIS)

We are doing this study to learn if the MMprofiler genomic test can help your doctor in making decisions about your treatment.

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An Open-Label, Multicenter, Phase 2 Study of CLR 131 in Patients with Relapsed or Refractory (R/R) Select B-Cell Malignancies

This is a multicenter, open-label, Phase 2 study evaluating intravenous (IV) administration of CLR 131 in patients with B-cell malignancies who have been previously treated with standard therapy for their underlying malignancy.

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