Selinexor

About This Treatment

Myeloma Clinical Trials


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Bortezomib, Selinexor, and Dexamethasone in Patients With Multiple Myeloma

This study will compare the efficacy and health-related quality of life (HR-QoL) and assess the safety of selinexor plus bortezomib (Velcade or generic equivalent) plus low-dose dexamethasone (SVd) versus bortezomib plus low-dose dexamethasone (Vd) in adult patients with relapsed or refractory multiple myeloma.

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Phase 1b/2 Study of Selinexor (KPT-330) in Combination w/ Backbone Treatments for Relapsed/Refractory Multiple Myeloma (STOMP)

This study will independently assess the efficacy and safety of three combination therapies for the treatment of patients with relapsed/refractory multiple myeloma (RR MM): selinexor + dexamethasone + pomalidomide (SdP) and selinexor + dexamethasone + bortezomib (SdB), selinexor + dexamtheasone + lenalidomide.

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A Study to Test the Combination of Selinexor (KPT-330), Ixazomib, and Dexamethasone in Patients With Myeloma

The purpose of this study is to test the safety of a combination of study drugs called selinexor (KPT-330) and ixazomib (MLN9708) with a low dose of dexamethasone.

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Selinexor Plus High-Dose Melphalan (HDM) Before Autologous Hematopoietic Cell Transplantation for Multiple Myeloma

Phase I: The primary purpose of this study phase is to determine the best dose also referred to as the maximum tolerated dose (MTD) of Selinexor when used in combination with high-dose melphalan as a conditioning regimen for hematopoietic cell transplant. Phase II: The primary purpose of this study phase is to assess the complete response (CR) conversion rate.

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Treatment Information
Developed By

Karyopharm Therapeutics

Treatment Classifications
Additional Names
  • KPT-330

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