John Theurer Cancer Center
Hackensack Meridian Health
Hackensack Meridian Health
The treatment of multiple myeloma is highly personalized at John Theurer Cancer Center, part of Hackensack University Medical Center in New Jersey. We are one of the few treatment centers in the nation offering a full team of specialized experts in the care of patients with all stages of multiple myeloma. If you have multiple myeloma, we carefully assess the stage and biology of your disease to match you with the best treatment, or to customize a surveillance program for you if you do not yet need therapy. When you come to us for your care, you’ll see the same physician at every visit who gets to know you and your family, is available to address your questions and concerns, and provides a personal level of care that can be hard to find elsewhere.
While two cases of multiple myeloma can look the same under the microscope and may appear to be the same disease, we now know that there are more than five different subsets of myeloma, each with its own biological features and behavior. That’s why we don’t take a one-size-fits-all approach to myeloma treatment. When you come to John Theurer Cancer Center for multiple myeloma care, we’ll perform a comprehensive molecular analysis of your cancer to determine its subtype, and match you with the most appropriate therapy. This “precision medicine” approach ensures that you receive the therapy that is best suited for the biology of your cancer, offering the greatest chance of success.
Our doctors are leaders in myeloma research. Their research efforts have resulted in some of the most promising treatments for myeloma used today, including bortezomib (Velcade), lenalidomide (Revlimid), and carfilzomib (Kyprolis). In addition, our team participated in the development of four myeloma therapies just approved over the last few years: daratumumab (Darzalex), elotuzumab (Empliciti), ixazomib (Ninlaro), and panobinostat (Farydak). What does this mean for you? It means your treatment team is not only knowledgeable about, but involved in the development of the very latest therapies for your disease—and therefore best equipped to provide you with the most advanced solutions.
John Theurer Cancer Center has one of the largest bone marrow or stem cell transplantation programs in the country for multiple myeloma, performing over 250 transplants a year. Our program features physicians whose primary focus is transplantation for multiple myeloma. We also perform more allogeneic transplants (using stem cells from a healthy donor) for multiple myeloma than any other center in our region. Our research has a strong focus on reducing the complications of transplantation and also lowering the risk of recurrence. For example, we are the first team in the world to combine checkpoint inhibitors (drugs that work by inhibiting the proteins cancer cells use to evade detection by the immune system) after transplantation, at a time where the newly reset immune system has the best opportunity to eliminate residual cancer cells.
Some people have diseases that have the potential to turn into multiple myeloma. These “precursor” disorders include smoldering multiple myeloma and MGUS (monoclonal gammopathy of undetermined significance). If you were diagnosed with one of these disorders, you may have been surprised because they don’t cause any symptoms. Our doctors take a conservative approach to treating patients with smoldering multiple myeloma and MGUS. We’ll monitor you and let you know if or when you may benefit from treatment. We also offer clinical trials assessing immunological factors and other predictors of the best time to start treatment.
The Institute for Multiple Myeloma will be located in a state-of-the art research facility at the Hackensack Meridian Health Interprofessional Health Sciences Campus in Nutley and Clifton, NJ, and led by founding director, Dr. David Siegel, chief of the Multiple Myeloma Division at John Theurer Cancer Center. Under the leadership of Dr. Siegel, and alongside hematology experts like Dr. André Goy, chairman and executive director, division chief of Lymphoma at John Theurer Cancer Center, the Institute will focus on driving innovative research, and continuing the development of precision medicine for each patient.
We bring together all the multiple myeloma experts you may need—offering dedicated highly specialized providers trained at the world’s best academic medical centers—from hematology/medical oncology, immunology, stem cell transplantation, infectious diseases, pathology, radiation oncology, orthopedics, and nursing to provide you with a tailored plan of care based on the specific features of your disease and your personal condition. Our goal is to treat your myeloma while taking into account all physical, functional, emotional, and quality of life aspects of your disease. We don’t just care for you, but about you. In fact, according to Press-Ganey surveys, 99 percent of our patients report satisfaction with their care.
We are doing this study to learn if the MMprofiler genomic test can help your doctor in making decisions about your treatment.
The purpose of this study is to evaluate the safety of the study drug, GSK2857916, at different doses and how well it works to treat people with multiple myeloma when taken together with Lenalidomide Plus Dexamethasone (Treatment Arm A), or Bortezomib Plus Dexamethasone (Treatment Arm B).
The MyDRUG study is a type of Precision Medicine trial to treat patients with drugs targeted to affect specific genes that are mutated as part of the disease. Mutations in genes can lead to uncontrolled cell growth and cancer. Patients with a greater than 30% mutation to any of the following genes; CDKN2C, FGFR3, KRAS, NRAS, BRAF V600E, IDH2 or T(11;14) can be enrolled to one of the treatment arms.
This is a multicenter, multicountry, open-label, Phase 1b/2a dose-escalation study to determine the maximum tolerated dose of CC-220 when administered as monotherapy and in combination with dexamethasone.
This phase I/II trial studies the side effects and best dose of idasanutlin and ixazomib citrate when given together with dexamethasone in treating patients with multiple myeloma that has returned after a period of improvement.
This is a Phase 1, first-in-human, multicenter; non-randomized, open-label and dose-exploration study of AMG 176 administered IV in subjects with relapsed or refractory multiple myeloma and subjects with relapsed or refractory acute myeloid leukemia.
This is a dose finding pilot study to evaluate the safety and determine the maximum tolerated dose of the combination of carfilzomib and pomalidomide with dexamethasone (CPD) in patients with relapsed or refractory multiple myeloma.
This is a trial of TTI-621 in subjects with relapsed or refractory hematologic malignancies and selected solid tumors.
This is a multicenter, randomized, open-label, Phase 3 study comparing the efficacy and safety of bb2121 versus standard triplet regimens in subjects with relapsed and refractory multiple myeloma (MM). The study is anticipated to randomize approximately 381 subjects with RRMM. Approximately 254 subjects will be randomized to Treatment Arm A and approximately 127 subjects will be randomized to Treatment Arm B.
This study is a multicenter, open-label, nonrandomized, sequential group, dose-escalation study to assess safety, tolerability, pharmacokinetics and preliminary anti-tumor activity of ascending doses of AZD5991 in subjects with relapsed or refractory hematologic malignancies.
Following consent, enrolled subjects will undergo a leukapheresis procedure to collect autologous mononuclear cells for manufacture of investigational drug product (bb21217). Following manufacture of the drug product, subjects will receive lymphodepletion prior to bb21217 infusion.
The purpose of the Molecular Profiling Initiative (MPI) is to provide timely CLIA genomic sequencing information to MM patients and their doctors, allowing them to make informed treatment decisions and identify potential treatment options based on a patient’s genomic alterations.
The purpose of this study is to determine the safety profile and maximum tolerable dose (MTD) of single-agent GBR 1342 in subjects with multiple myeloma who have received prior therapies.
This study is a multi-cohort, open-label, multicenter Phase 2 study to determine the efficacy and safety of bb2121 in subjects with relapsed and refractory MM (Cohort 1) and in subjects with HR MM having progressed within one year of initial treatment (Cohort 2).
High dose chemotherapy with stem cell transplantation is commonplace in the treatment of multiple myeloma. This treatment uses a chemotherapy drug called Melphalan that has been used in several thousand bone marrow transplant recipients worldwide for the same or similar disorders.
This study will find the highest acceptable treatment dose and timing of infusion of cord blood, culture expanded natural killer (NK) cells, a kind of immune cell, in patients with multiple myeloma.
In this study the investigators are comparing this standard regimen to the newly established regimen of melphalan and bortezomib.
The purpose of this First-in-Human Phase 1 study is to determine during the escalation part if AMG 701 given as weekly short term IV infusions is safe and tolerable followed by a dose expansion part to gain further efficacy and safety experience with AMG 701 in adult subjects with relapsed / refractory multiple myeloma.
This Phase 1 study will evaluate the safety and feasibility of an investigational CAR-T cell therapy called Descartes-08 in eligible patients with active multiple myeloma.
This is an open-label, multicenter, Phase 1/2 study to determine the safety and efficacy of JCARH125, a CAR T-cell product that targets B-cell maturation antigen (BCMA), in adult subjects with relapsed or refractory multiple myeloma.
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Hackensack, NJ 07601
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