Multiple Myeloma

Treatment Classifications

The following is a list of treatment classifications in development for multiple myeloma that are currently recruiting myeloma patients in the United States. You can use the buttons below to filter by diagnosis and sort the listings by name or active number of trials.


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Immunotherapy
Immunotherapy involves the use of many active agents such as cells, cytokines or vaccines (among others). These agents are used to induce, enhance or suppress the function of the immune system.
Proteasome Inhibitor
Proteasome Inhibitors can block cancer cells from removing defective proteins, which can lead to cell death.
Stem Cell Transplants
Stem cell transplants use a patient's own stem cells (autologous) or those from a donor (allogeneic) to rescue the bone marrow from the intense effects of high dose of chemotherapy.
Monoclonal Antibody
Antibodies are cloned and used to attack one specific type of protein found in cancer cells.
Immunomodulatory Drugs (IMID)
Immunomodulatory therapies typically involve special chemicals called cytokines. These therapies are designed to enhance the immune system to fight cancer.
Adoptive Cellular Therapy
In adoptive cellular therapy, T cells are removed from a patient, genetically modified or treated with chemicals to enhance their activity, and then re-introduced into the patient with the goal of improving the immune system’s anti-cancer response.
Vaccines
Cancer vaccines are designed to stimulate an immune response against tumor-specific or tumor-associated antigens, encouraging the immune system to attack cancer cells bearing these antigens.
Histone Deacetylase (HDAC) Inhibitor
HDAC Inhibitors can block proteins that tell the cancer cell to grow and divide, which can cause cell death.
Tyrosine Kinase (TK) Inhibitor
Tyrosine Kinase Inhibitors can block the cancer cell from growing and dividing by stopping messages from being passed by chemicals within the cell.
Checkpoint Inhibitor
Immune checkpoint inhibitors are drugs – often made of antibodies – that unleash an immune system attack on cancer cells.
Bruton's Tyrosine Kinase (BTK) Inhibitor
Brutons Tyrosine Kinase Inhibitors can block the cancer cell from growing and dividing by stopping messages from being passed by chemicals within the cell.
Selective Inhibitor of Nuclear Export (SINE)
Selective Inhibitor of Nuclear Export (SINE) causes the accumulation of suppressor proteins in the nucleus of cancer cells leading to cell death.
Mammalian Target of Rapamycin (mTOR) Inhibitor
mTOR Inhibitors can block chemicals in the cancer cell that tell it to grow and create new blood vessels.
BCL-2 Inhibitor
BCL-2 Inhibitors can work by blocking chemicals a cancer cell creates to protect itself so that cell death can occur.
Bromodomain and Extra-Terminal Protein (BET) Inhibitor
BET Inhibitors can work by blocking chemicals that tell the cancer cell to grow.
MEK Inhibitor
MEK Inhibitors can interrupt cell activity which can cause the cancer cell to attack itself.
Kinase Inhibitor
Kinase Inhibitors can work by blocking the activity of proteins in the cell that control cell growth and division.
Antibody Drug Conjugates
Antibody Drug Conjugates (ADCs) are monoclonal antibodies (mAbs) attached to biologically active drugs by chemical linkers with labile bonds. By combining the unique targeting of mAbs with the cancer-killing ability of cytotoxic drugs, ADCs allow sensitive discrimination between healthy and diseased tissue.
Cyclin-Dependent Kinases (CDK) Inhibitor
Cyclin Dependent Kinase Inhibitors can block chemicals that are responsible for telling cancer cells to rapidly divide and grow.
Nucleoside Metabolic Inhibitor
Nucleoside Metabolic Inhibitors can work by being absorbed by the cancer cell and changing it’s DNA to slow down it’s function and growth.
Pan-PIM Protein Kinase Inhibitor
Pan-PIM Protein Kinase Inhibitors can work by blocking chemicals in the cancer cell that control cell growth and survival.