This phase II trial is studying how well giving fludarabine and cyclophosphamide together with total-body irradiation followed by an umbilical cord blood transplant, sirolimus, and mycophenolate mofetil works in treating patients with hematologic cancer.
RATIONALE:
Drugs used in chemotherapy, such as fludarabine and cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill cancer cells.
An umbilical cord blood transplant may be able to replace blood-forming cells that were destroyed by chemotherapy and radiation therapy. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells. Giving sirolimus and mycophenolate mofetil after the transplant may stop this from happening.
SparkCures ID | 98 |
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Trial Phase | Phase 2 |
Enrollment | 320 Patients |
Treatments |
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Trial Sponsors |
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NCT Identifier |
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The following criteria is a partial list of reasons why patients may or may not be eligible to participate in this clinical trial. Further evaluation with a medical professional will be required to determine full eligibility.
The following criteria is provided for health care professionals.
Inclusion Criteria:
Age, Graft Cell Dose and Graft HLA Criteria
Disease Criteria:
Adequate Organ Function and Performance Status
Exclusion Criteria:
Please visit the ClinicalTrials.gov page for historical site information.
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