The following criteria is provided for health care professionals.

Inclusion Criteria:

• Signed, written informed consent.
• Sex: male or female.
• Age: >=18 years of age at the time of providing informed consent.
• Eastern Cooperative Oncology Group (ECOG) performance status: 0, 1 or 2.
• BRAF V600E mutation-positive tumor: Local testing - Local BRAF mutation test results obtained by a Clinical Laboratory Improvement Amendments (CLIA) approved local laboratory may be used to permit enrollment of subjects with positive results. Local BRAF mutation test results will be subject to central verification; Central testing - Local BRAF mutation test results will be confirmed by central testing in a CLIA approved, designated central reference laboratory by the THxID BRAF assay or an alternate GSK designated assay. NOTE: For central testing, Formalin-fixed paraffin-embedded (FFPE) core bone marrow (BM) biopsies are not acceptable from subjects in the Multiple myeloma (MM) cohort.
• Able to swallow and retain orally administered medication. NOTE: Subject should not have any clinically significant gastrointestinal (GI) abnormalities that may alter absorption such as malabsorption syndrome or major resection of the stomach or bowels. For example, subjects should have no more than 50% of the large intestine removed and no sign of malabsorption (i.e., diarrhea).NOTE: If clarification is needed as to whether a condition will significantly affect the absorption of study treatments, contact the GSK Medical Monitor.
• Female Subjects of Childbearing Potential: Subjects must have a negative serum pregnancy test within 7 days prior to the first dose of study treatment and agrees to use effective contraception, throughout the treatment period and for 4 months after the last dose of study treatment.
• French subjects: In France, a subject will be eligible for inclusion in this study only if either affiliated to or a beneficiary of a social security category.

Exclusion Criteria:

• Prior treatment with: BRAF and/or MEK inhibitor(s); anti-cancer therapy (e.g., chemotherapy with delayed toxicity, immunotherapy, biologic therapy or chemoradiation) within 21 days (or within 42 days if prior nitrosourea or mitomycin C containing therapy) prior to enrollment and/or daily or weekly chemotherapy without the potential for delayed toxicity within 14 days prior to enrolment; Investigational drug(s) within 30 days or 5 half-lives, whichever is longer, prior to enrollment
• Previous major surgery within 21 days prior to enrollment.
• Prior extensive radiotherapy treatment within 21 days prior to enrolment. NOTE: Limited radiotherapy for palliative care is permitted within 14 days prior to enrollment as long as any radiation-related toxicity has resolved prior to enrollment.
• Prior solid organ transplantation or allogenic stem cell transplantation (ASCT). NOTE: Previous autologous bone marrow transplant (ABMT) or autologous peripheral blood stem cell transplant (PBSCT) is permitted.
• History of: Interstitial lung disease or pneumonitis; Another malignancy. NOTE: Subjects with another malignancy are eligible if: (a) disease-free for 3 years, (b) had a history of completely resected non-melanoma skin cancer, and/or (c) have a indolent second malignancy(ies) defined as a slow growing second/concurrent malignancy which is characterized by slow growth, a high initial response rate and a relapsing , progressive disease course. For example, a previously untreated low grade and select intermediate-grade lymphoid malignancy would be allowed as per the available body of evidence. There are no available clinical alternatives to the proposed population. Consult a GSK Medical Monitor if unsure whether second malignancies meet requirements specified above.
• Presence of: cerebral metastases (except for subjects in the WHO Grade 1 or 2 Glioma or WHO Grade 3 or 4 Glioma histology cohorts). NOTE: Subjects with brain metastases may be included if: All known lesions have been previously treated with surgery or stereotactic radiosurgery, and Any remaining cerebral lesion(s) are asymptomatic and confirmed stable disease (i.e., no increase in lesion size) for >=90 days prior to enrollment as documented by two consecutive magnetic resonance imaging (MRI) or computed tomography (CT) scans with contrast, and No treatment with corticosteroids or enzyme-inducing anticonvulsants required for >=30 days prior to enrolment. Approval received from GSK Medical Monitor.
• Presence of symptomatic or untreated leptomeningeal or spinal cord compression. NOTE: Subjects who have been previously treated for these conditions and have stable central nervous system (CNS) disease (documented by consecutive imaging studies) for >60 days, are asymptomatic and currently not taking corticosteroids, or have been on a stable dose of corticosteroids for at least 30 days prior to enrollment, are permitted.
• Presence of pre-existing >= Grade 2 peripheral neuropathy.
• Presence of unresolved treatment-related toxicity of >= Grade 2 (except alopecia) or toxicities listed in the general and histology-specific adequate organ function tables at the time of enrolment.
• Presence of any serious and/or unstable pre-existing medical disorder (aside from malignancy exception above), psychiatric disorder, or other conditions that could interfere with subject's safety, obtaining informed consent or compliance to the study procedures.
• History or current evidence/risk of retinal vein occlusion (RVO) or central serous retinopathy (CSR): History of RVO or CSR, or predisposing factors to RVO or CSR (e.g., uncontrolled glaucoma or ocular hypertension, uncontrolled systemic disease such as hypertension or diabetes mellitus, or history of hyperviscosity or hypercoagulability syndromes); Visible retinal pathology as assessed by ophthalmic examination that is considered a risk factor for RVO or CSR such as evidence of new optic disc cupping, evidence of new visual field defects and intraocular pressure >21 mmHg.
• History or evidence of cardiovascular risk including any of the following: Acute coronary syndromes (including myocardial infarction and unstable angina), coronary angioplasty, or stenting within 6 months prior to enrolment; Clinically significant uncontrolled arrhythmias NOTE: Subjects with controlled atrial fibrillation for >30 days prior to enrollment are eligible; Class II or higher congestive heart failure as defined by the New York Heart Association (NYHA) criteria; Left ventricular ejection fraction (LVEF) below the institutional lower limit of normal (LLN). NOTE: If a LLN does not exist at an institution, then use LVEF <50%.; Corrected QT (QTc) interval for heart rate using Bazett-corrected QT interval (QTcB) >=480 millisecond (msec); Intracardiac defibrillator and/or permanent pacemaker; Treatment-refractory hypertension defined as a blood pressure (BP) >140/90 millimeters of mercury (mmHg) which may not be controlled by anti-hypertensive medication(s) and/or lifestyle modifications; Known cardiac metastases.
• Current use of prohibited medication(s) or requirement of prohibited medications during study. NOTE: Use of anticoagulants such as warfarin is permitted; however, international normalization ratio (INR) must be monitored according with local institutional practice.
• Positive for: Hepatitis B surface antigen or Hepatitis C antibody. NOTE: Subjects with laboratory evidence of cleared hepatitis B virus (HBV) and hepatitis C virus (HCV) infection will be permitted. NOTE: False positive subjects may be cleared for enrollment based on RNA-based assays; Human immunodeficiency virus (HIV); testing not required.
• Known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to study treatment, or excipients, or to dimethyl sulfoxide and/or sulfonamides (structural component of dabrafenib).
• Female subjects: Pregnant, lactating or actively breastfeeding.
• Subjects enrolled in France: The French subject has participated in any study using an investigational product (IP) within 30 days prior to enrollment in this study.